iPRMT1 | PRMT1 inhibitor | Probechem Biochemicals

Chemical Structure : iPRMT1

iPRMT1 (PRMT1 inhibitor)

Catalog No.: PC-21345Not For Human Use, Lab Use Only.

iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs.

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Biological Activity

iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs.
iPRMT1 inhibitscell growth with an EC50 of 90, 70, and 9 nM in MCF7, T47D, and MDA-MB-231 cells, respectively, while it has minimal cellular toxicity toward normal breast epithelial cells, MCF10A.
iPRMT1 inhibits PRMT1-mediated SRSF1 methylation, alternative splicing events, and breast cancer cell growth and tumorigenesis.
Combination treatment with iPRMT1 and SRSF1 phosphorylation inhibitor exhibits additive effects on suppressing breast cancer cell growth and tumorigenesis.

Physicochemical Properties

M.Wt	428.50
Formula	C24H24N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-6a,7-dihydroindolo[2,1-h]pteridin-6(5H)-one

References

1. Wen-Juan Li, et al. Cell Rep. 2023 Nov 7;42(11):113385.