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Chemical Structure : iST2-1
CAS No.: 1019158-02-1
Catalog No.: PC-35645Not For Human Use, Lab Use Only.
iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively.
iST2-1 decrease IFN-γ-producing T cell populations in the in vitro mixed lymphocyte reaction assays.
iST2-1 reduces plasma sST2 levels, alleviate GVHD, and improve survival in vivo, ameliorates GVHD burden and maintains GVL effect in the murine MLL-AF9 leukemia model.
| M.Wt | 378.428 | |
| Formula | C22H22N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-methoxyphenyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrrolidine |
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1. Ramadan AM, et al. JCI Insight. 2018 Jul 25;3(14). pii: 99208.
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