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mTOR inhibitor 10

Chemical Structure : mTOR inhibitor 10

CAS No.: 1222999-54-3

mTOR inhibitor 10

Catalog No.: PC-60920Not For Human Use, Lab Use Only.

mTOR inhibitor 10 is a potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    mTOR inhibitor 10 is a potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM.
    mTOR inhibitor 10 displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.).
    mTOR inhibitor 10 exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.

    Physicochemical Properties

    M.Wt 683.735
    Formula C41H32F3N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(1-methylpiperidin-4-yl)-4'-(2-oxo-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxamide

    References

    1. Liu Q, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4036-40.

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