Catalog No.: PC-60920Not For Human Use, Lab Use Only.
mTOR inhibitor 10 is a potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM.
mTOR inhibitor 10 is a potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM.
mTOR inhibitor 10 displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.).
mTOR inhibitor 10 exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.
