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mitoNEET Ligand-1

Chemical Structure : mitoNEET Ligand-1

CAS No.: 188532-26-5

mitoNEET Ligand-1 (NL-1)

Catalog No.: PC-38243Not For Human Use, Lab Use Only.

mitoNEET Ligand-1 (NL-1) is a small molecule ligand of mitoNEET, a protein that regulate the oxidative capacity of the mitochondria.

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Biological Activity

mitoNEET Ligand-1 (NL-1) is a small molecule ligand of mitoNEET, a protein that regulate the oxidative capacity of the mitochondria.
mitoNEET is a viable target for the design and synthesis of novel therapeutic agents aimed at altering mitochondrial function.
NL-1 uncoupled isolated mitochondrial complex I respiration with an IC50 of 2.4 μM and inhibited state III respiration up to 45%, protected the human neuronal cell line SH-SY5Y against rotenone induced cell death.
NL-1 reduced expression of mRNA encoding pro-inflammatory cytokines IL-1β, IL-6, and TNFα, and of mRNA encoding inflammatory mediators iNOS and COX2 in RAW264.7 cells.
NL-1 also reduced expression of mRNA encoding iNOS and COX2 in the spleen and liver of mice with LPS-induced sepsis in injected mice, attenuated LPS-induced oxidative stress and mitochondrial dysfunction.

Physicochemical Properties

M.Wt 335.462
Formula C18H25NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one

References

1. Logan SJ, et al. Basic Res Cardiol. 2015 Mar;110(2):19.

2. Lee S, et al. Cell Death Dis. 2022 Feb 8;13(2):127.

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