msR4M-L1 is a chemokine-selective CXCR4 ectodomain mimic that selectively binds to migration inhibitory factor (MIF)(KD<40 nM) but not CXCL12 (>140-fold selectivity)。
msR4M-L1 has potency compares well with established MIF inhibitors, whereas msR4M-L1 does not interfere with cardioprotective MIF/CD74 signaling.
msR4M-L1 enriches in atherosclerotic plaques, blocks arterial leukocyte adhesion, and inhibits atherosclerosis and inflammation in hyperlipidemic Apoe-/- mice in vivo.
msR4M-L1 has the full name as "MIF-specific human CXCR4 mimic-ECL1[97–110]-6-Ahx-12-Ado-ECL2[182–196].
Physicochemical Properties
M.Wt
Formula
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
MIF-specific human CXCR4 mimic-ECL1[97-110]-6-Ahx-12-Ado-ECL2[182-196]
References
1. Christos Kontos, et al. Nat Commun. 2020 Nov 25;11(1):5981.
