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Chemical Structure : msR4M-L1
Catalog No.: PC-38320Not For Human Use, Lab Use Only.
msR4M-L1 is a chemokine-selective CXCR4 ectodomain mimic that selectively binds to MIF (KD<40 nM) but not CXCL12 (>140-fold selectivity).
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msR4M-L1 is a chemokine-selective CXCR4 ectodomain mimic that selectively binds to migration inhibitory factor (MIF) (KD<40 nM) but not CXCL12 (>140-fold selectivity)。
msR4M-L1 has potency compares well with established MIF inhibitors, whereas msR4M-L1 does not interfere with cardioprotective MIF/CD74 signaling.
msR4M-L1 enriches in atherosclerotic plaques, blocks arterial leukocyte adhesion, and inhibits atherosclerosis and inflammation in hyperlipidemic Apoe-/- mice in vivo.
msR4M-L1 has the full name as "MIF-specific human CXCR4 mimic-ECL1[97–110]-6-Ahx-12-Ado-ECL2[182–196].
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Christos Kontos, et al. Nat Commun. 2020 Nov 25;11(1):5981.
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