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nTRD22

Chemical Structure : nTRD22

CAS No.: 1065567-62-5

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nTRD22 (TDP-43 inhibitor nTRD22)

Catalog No.: PC-73021Not For Human Use, Lab Use Only.

nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.
    nTRD22 likely elicits TDP-43 phase separation and TDP-43 degradation by blocking RNA binding.
    nTRD22 mitigates motor defects in a Drosophila model of ALS overexpressing TDP-43.

    Physicochemical Properties

    M.Wt 413.397
    Formula C19H22F3N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-(3-hydroxypiperidin-1-yl)ethyl)-5-((3-(trifluoromethyl)phenoxy)methyl)isoxazole-3-carboxamide

    References

    1. Mollasalehi N, et al. ACS Chem Biol. 2020 Nov 20;15(11):2854-2859.

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