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Chemical Structure : o-Phenanthroline
CAS No.: 66-71-7
Catalog No.: PC-61352Not For Human Use, Lab Use Only.
o-Phenanthroline is a selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $58 | In stock | |
| 250 mg | $88 | In stock | |
| 500 mg | $128 | In stock | |
| 1 g | Get quote |
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o-Phenanthroline is a selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM.
o-Phenanthroline shows no activity for other DUBs (USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37, IC50>50 uM).
o-Phenanthroline blocks cellular proteasome function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib, activates caspase cascade and endoplasmic stress response signaling.
o-Phenanthroline reduces progression of tumor growth and prolongs survival in mice MM xenograft model.
| M.Wt | 180.21 | |
| Formula | C12H8N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,5-Diazaphenanthrene |
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1. Song Y, et al. Oncogene. 2017 Jun 5. doi: 10.1038/onc.2017.172.
2. Verma R, et al. Science. 2002 Oct 18;298(5593):611-5.
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