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Chemical Structure : pan AMPK activator compound 1
Catalog No.: PC-22496Not For Human Use, Lab Use Only.
pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively.
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pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively.
pan-AMPK activator compound 1 dose-dependently activates AMPK in whole blood cells and kidney.
pan-AMPK activator compound 1 improves kidney function and protects the tubules.
pan-AMPK activator compound 1 suppresses hypoxia-induced apoptosis in proximal tubule cells by improving the efficiency of oxidative phosphorylation.
pan-AMPK activator compound 1 preserves kidney function during ischemia/reperfusion injury in rats.
| M.Wt | 486.91 | |
| Formula | C23H23ClN4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Frikke-Schmidt H, et al. J Pharmacol Exp Ther. 2024 Jun 7:JPET-AR-2024-002120.
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