Chemical Structure : pan AMPK activator compound 1
CAS No.:
pan AMPK activator compound 1
(AMPK activator compound 1)
Catalog No.: PC-22496Not For Human Use, Lab Use Only.
pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
pan-AMPK activator compound 1 is a potent, selective small molecule pan AMPK activator with EC50 of 25.9/259 nM and 72.7/170 nM for human and rat α1β2γ1/α2β1γ1, respectively.
pan-AMPK activator compound 1 dose-dependently activates AMPK in whole blood cells and kidney.
pan-AMPK activator compound 1 improves kidney function and protects the tubules.
pan-AMPK activator compound 1 suppresses hypoxia-induced apoptosis in proximal tubule cells by improving the efficiency of oxidative phosphorylation.
pan-AMPK activator compound 1 preserves kidney function during ischemia/reperfusion injury in rats.
Physicochemical Properties
|
M.Wt
|
486.91
|
|
Formula
|
C23H23ClN4O6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(3R,3aR,6R,6aR)-6-((6-chloro-5-((R)-1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazin-8-yl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol
|
References
1. Frikke-Schmidt H, et al. J Pharmacol Exp Ther. 2024 Jun 7:JPET-AR-2024-002120.
Contact Us
sales@probechem.com
