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rTRD01

Chemical Structure : rTRD01

CAS No.: 1332175-56-0

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rTRD01

Catalog No.: PC-73020Not For Human Use, Lab Use Only.

rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.
    rTRD01 inhibited (GGGGCC)4 interaction for TDP-43 102–269 with IC50 of 150 uM.
    rTRD01 improved larval turning in a Drosophila model of amyotrophic lateral sclerosis (ALS).

    Physicochemical Properties

    M.Wt 344.39
    Formula C18H21FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-[3-(4-Fluorobenzyl)-3-(hydroxymethyl)piperidin-1-yl]pyrazine-2-carboxamide

    References

    1. François-Moutal L, et al. ACS Chem Biol. 2019 Sep 20;14(9):2006-2013.

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