rTRD01

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Chemical Structure : rTRD01

Catalog No.: PC-73020Not For Human Use, Lab Use Only.

rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.

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Biological Activity

rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.
rTRD01 inhibited (GGGGCC)4 interaction for TDP-43 102–269 with IC50 of 150 uM.
rTRD01 improved larval turning in a Drosophila model of amyotrophic lateral sclerosis (ALS).

Physicochemical Properties

M.Wt	344.39
Formula	C18H21FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[3-(4-Fluorobenzyl)-3-(hydroxymethyl)piperidin-1-yl]pyrazine-2-carboxamide

References

1. François-Moutal L, et al. ACS Chem Biol. 2019 Sep 20;14(9):2006-2013.

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rTRD01

Biological Activity

Physicochemical Properties

References

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