sAJM-589 (sAJM589) is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.
sAJM-589 preferentially inhibits transcription of MYC target genes in P493-6 cell.
sAJM-589 suppresses cellular proliferation in diverse MYC-dependent cancer cell lines, including P493-6, Ramos, HL-60 and KG1a (IC50=0.8-2 uM).
sAJM-589 reduces Myc protein levels in these cells, possibly by promoting ubiquitination and degradation of Myc protein.
Physicochemical Properties
M.Wt
246.269
Formula
C16H10N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Benzo[a]phenazin-5-ol
References
1. Choi SH, et al. ACS Chem Biol. 2017 Oct 4. doi: 10.1021/acschembio.7b00799.
