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sAKZ692

Chemical Structure : sAKZ692

CAS No.: 950430-20-3

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sAKZ692 (sAKZ-692, sAKZ 692)

Catalog No.: PC-20849Not For Human Use, Lab Use Only.

sAKZ692 (sAKZ-692) is a small molecule activator of NRF2 transcriptional activity (EC50=2.2 uM) in cells by inhibiting the glycolytic enzyme pyruvate kinase.

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    Biological Activity

    sAKZ692 (sAKZ-692) is a small molecule activator of NRF2 transcriptional activity (EC50=2.2 uM) in cells by inhibiting the glycolytic enzyme pyruvate kinase.
    sAKZ692 treatment promotes the buildup of glyceraldehyde 3-phosphate, a metabolite which leads to S-lactate modification of cysteine sensor residues of KEAP1, resulting in NRF2-dependent transcription.

    Physicochemical Properties

    M.Wt 367.36
    Formula C19H15F2N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-(5-fluoro-1H-indol-3-yl)ethyl)-1-(4-fluorophenyl)-1H-1,2,3-triazole-4-carboxamide

    References

    1. Yeonjin Ko, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2300763120.

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