Catalog No.: PC-49731Not For Human Use, Lab Use Only.
trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93).
trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93).
trans-MiM111 is metabolically stable with good nervous system bioavailability.
trans-MiM111 promotes the relaxed/active MFN2 conformation without affecting catalytic GTPase activity.
trans-MiM111 (50 mg/kg given orally once daily) causes transient "burst" mitofusin activation in 50-week-old MFN2 T105M mice.
