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Chemical Structure : trans-MiM111
Catalog No.: PC-49731Not For Human Use, Lab Use Only.
trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93).
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trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93).
trans-MiM111 is metabolically stable with good nervous system bioavailability.
trans-MiM111 promotes the relaxed/active MFN2 conformation without affecting catalytic GTPase activity.
trans-MiM111 (50 mg/kg given orally once daily) causes transient "burst" mitofusin activation in 50-week-old MFN2 T105M mice.
| M.Wt | 289.42 | |
| Formula | C18H27NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Antonietta Franco, et al. Elife. 2020 Oct 19;9:e61119.
2. Dang X, et al. J Med Chem 64:12506–12524.
3. Franco A, et al. J Pharmacol Exp Ther. 2022 Nov;383(2):137-148.
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