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Chemical Structure : trans Ned 19
CAS No.: 1354235-96-3
Catalog No.: PC-62184Not For Human Use, Lab Use Only.
trans Ned 19 is a cell-permeant chemical probe for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling (IC50=6 nM, inhibition of Ca2+ release).
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
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| 100 mg | Get quote |
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trans Ned 19 is a cell-permeant chemical probe for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling (IC50=6 nM, inhibition of Ca2+ release).
trans Ned 19 blocks NAADP signaling and fluorescently labeled NAADP receptors in intact cells.
trans Ned-19 antagonizes NAADP-activation of TPC2 in a non-competitive manner at 1 uM.
| M.Wt | 514.601 | |
| Formula | C30H31FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,3S)-1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid |
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1. Naylor E, et al. Nat Chem Biol. 2009 Apr;5(4):220-6.
2. Ali RA, et al. J Biol Chem. 2016 Feb 26;291(9):4503-22.
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