Chemical Structure : z-IETD-FMK
CAS No.:
210344-98-2
z-IETD-FMK
(Z-IE(OMe)TD(OMe)-FMK)
Catalog No. : PC-24248Not For Human Use, Lab Use Only.
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2424801
Biological Activity
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM.
Physicochemical Properties
M.Wt
654.69
Formula
C30H43FN4O11
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
L-Threoninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
References
1. Martin DA, et al. J Biol Chem. 1998 Feb 20;273(8):4345-9.
2. Mocanu MM, et al. Br J Pharmacol. 2000 May;130(2):197-200.
3. Cowburn AS, et al. Blood. 2005 Apr 1;105(7):2970-2.
4. Bourne CM, et al. bioRxiv [Preprint]. 2025 Feb 27:2025.02.23.639785.
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