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z-LEHD-FMK

Chemical Structure : z-LEHD-FMK

CAS No.: 210345-04-3

z-LEHD-FMK

Catalog No.: PC-24251Not For Human Use, Lab Use Only.

z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis, exhibits the neuroprotective effect in rat model of spinal cord trauma.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis, exhibits the neuroprotective effect in rat model of spinal cord trauma.

Physicochemical Properties

M.Wt 690.73
Formula C32H43FN6O10
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-14-(2-fluoroacetyl)-5-isobutyl-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

References

1. Xiao Y, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):8-14.

2. Ozoren N, et, al. Cancer Res. 2000 Nov 15; 60(22): 6259-65.

3. Mocanu MM, et, al. Br J Pharmacol. 2000 May; 130(2): 197-200.

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