α-Fluoromethylhistidine dihydrochloride | Histidine decarboxylase inhibitor

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Chemical Structure : α-Fluoromethylhistidine dihydrochloride

α-Fluoromethylhistidine dihydrochloride (α-FMH dihydrochloride, alpha-Fluoromethylhistidine)

Catalog No.: PC-28396Not For Human Use, Lab Use Only.

alpha-fluoromethylhistidine (α-FMH) is an orally active, irreversible histamine producing enzyme histidine decarboxylase (HDC) inhibitor with IC50 of 1-2 uM for soluble histidine decarboxylase preparations, inhibits histamine synthesis with IC50 of 0.2 uM in intact cell suspensions.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	260.09
Formula	C7H12Cl2FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((1H-Imidazol-4-yl)methyl)-2-amino-3-fluoropropanoic acid dihydrochloride

References

1. WoldeMussie E, et al. Mol Pharmacol. 1985 Aug;28(2):191-9.

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α-Fluoromethylhistidine dihydrochloride (α-FMH dihydrochloride, alpha-Fluoromethylhistidine)

Biological Activity

Physicochemical Properties

References

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