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Chemical Structure : β-catenin-IN-11a
Catalog No.: PC-62707Not For Human Use, Lab Use Only.
β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex.
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β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex.
β-catenin-IN-11a blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells.
| M.Wt | 504.59 | |
| Formula | C31H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Radwan AA, et al. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70.
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