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β-catenin-IN-11a

Chemical Structure : β-catenin-IN-11a

CAS No.: 1884472-26-7

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β-catenin-IN-11a

Catalog No.: PC-62707Not For Human Use, Lab Use Only.

β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex.
    β-catenin-IN-11a blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells.

    Physicochemical Properties

    M.Wt 504.59
    Formula C31H28N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N'-(1-((benzyl(methyl)amino)methyl)-2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazide

    References

    1. Radwan AA, et al. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70.

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