β-catenin inhibitor C2

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Chemical Structure : β-catenin inhibitor C2

Catalog No.: PC-72072Not For Human Use, Lab Use Only.

β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.

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Biological Activity

β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.
β-catenin inhibitor C2 reduced viability of DLD1 and SW480 cells in dose-dependent manner with IC50 ranging between 0.8-1.3 uM, viability of HCT116 and SW48 with IC50 3.45-5.35 uM.
β-catenin inhibitor C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells.

Physicochemical Properties

M.Wt	484.25
Formula	C19H20Br2N2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(3,5-dibromo-2-hydroxystyryl)-3-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yl)thiourea

References

1. Anton Cheltsov, et al. Sci Rep. 2020 May 15;10(1):8096.

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