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(R)-BA-1049

Chemical Structure : (R)-BA-1049

CAS No.: 1973494-16-4

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(R)-BA-1049 (BA-1049 R-form, (R)-BA1049, NRL-1049)

Catalog No.: PC-20084Not For Human Use, Lab Use Only.

(R)-BA-1049 (NRL-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-BA-1049 (NRL-1049) is a potent, orally-available ROCK2-selective inhibitor with IC50 of 0.24 uM, 16-fold selectivity over ROCK-1.
    Neither BA-1049 nor the metabolite inhibits PKA or PKC at physiological ATP concentrations.
    BA-1049 is a promising drug candidate to reduce lesion growth and hemorrhage in both CCM1 and CCM3 models of cavernous angioma (CA).

    Physicochemical Properties

    M.Wt 319.42
    Formula C16H21N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine

    References

    1. Lisa McKerracher, et al. Transl Stroke Res. 2020 Jun;11(3):365-376.

    2. Patent US20170313680A1.

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