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Chemical Structure : (R)-LW-Srci-8
Catalog No.: PC-22492Not For Human Use, Lab Use Only.
(R)-LW-Srci-8 is a potent, selective, covalent inhibitor of autophosphorylation site in c-Src kinase with IC50 of 35.83 nM.
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(R)-LW-Srci-8 is a potent, selective, covalent inhibitor of autophosphorylation site in c-Src kinase with IC50 of 35.83 nM.
(R)-LW-Srci-8 covalently bound to c-Src in a ratio of 1:1 through Michael addition reaction.
(R)-LW-Srci-8 selectively engages with c-Src and disrupts its downstream signaling in cells, including autophosphorylation at Y419.
(R)-LW-Srci-8 effectively increases c-Src thermal stability and reduces Y419 phosphorylation in CAL-62 cells.
(R)-LW-Srci-8 effectively suppresses the migration ability of c-SrcWT CAL-62 cells.
| M.Wt | 348.39 | |
| Formula | C19H22F2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huimin Zhang, et al. ACS Chem Biol. 2024 Apr 19;19(4):999-1010.
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