(R)-LW-Srci-8 | c-Src inhibitor | Probechem Biochemicals

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Chemical Structure : (R)-LW-Srci-8

(R)-LW-Srci-8 (c-Src inhibitor)

Catalog No.: PC-22492Not For Human Use, Lab Use Only.

(R)-LW-Srci-8 is a potent, selective, covalent inhibitor of autophosphorylation site in c-Src kinase with IC50 of 35.83 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

(R)-LW-Srci-8 is a potent, selective, covalent inhibitor of autophosphorylation site in c-Src kinase with IC50 of 35.83 nM.
(R)-LW-Srci-8 covalently bound to c-Src in a ratio of 1:1 through Michael addition reaction.
(R)-LW-Srci-8 selectively engages with c-Src and disrupts its downstream signaling in cells, including autophosphorylation at Y419.
(R)-LW-Srci-8 effectively increases c-Src thermal stability and reduces Y419 phosphorylation in CAL-62 cells.
(R)-LW-Srci-8 effectively suppresses the migration ability of c-SrcWT CAL-62 cells.

Physicochemical Properties

M.Wt	348.39
Formula	C19H22F2N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2-(cyclopentylamino)-1-(3,5-difluorophenyl)-2-oxoethyl)-N-cyclopropylacrylamide

References

1. Huimin Zhang, et al. ACS Chem Biol. 2024 Apr 19;19(4):999-1010.

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