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4-BBPB

Chemical Structure : 4-BBPB

CAS No.: 201216-39-9

4-BBPB (BBPB)

Catalog No.: PC-61602Not For Human Use, Lab Use Only.

4-BBPB is a highly potent agonist of sigma 1 receptor (σ1 receptor) with Ki of 0.8 nM.

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    Biological Activity

    4-BBPB is a highly potent agonist of sigma 1 receptor (σ1 receptor) with Ki of 0.8 nM.
    4-BBPB attenuates activity of neuronal nitric oxide synthase (nNOS), blunts ischemia-induced nitric oxide production, and provides neuroprotection in stroke models.

    Physicochemical Properties

    M.Wt 293.454
    Formula C21H27N
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-phenyl-1-(4-phenylbutyl) piperidine

    References

    1. Takahashi H, et al. Stroke. 1995 Sep;26(9):1676-82.

    2. Narita N, et al. Eur J Pharmacol. 1995 Oct 6;293(3):277-80.

    3. Yang ZJ, et al. Exp Neurol. 2010 Jan;221(1):166-74.

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