Chemical Structure : A1R PAM 56
CAS No.:
A1R PAM 56
Catalog No.: PC-24974Not For Human Use, Lab Use Only.
A1R PAM 56 is a potent, selective positive allosteric modulator of A1 adenosine receptor (A1R), modulates NECA affinity (pK) and potency (pEC50).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A1R PAM 56 is a potent, selective positive allosteric modulator of A1 adenosine receptor (A1R), modulates NECA affinity (pK) and potency (pEC50).
A1R PAM 56 does not activate the other three adenosine receptor subtypes or the M2 receptor, a distinct family A GPCR.
A1R PAM 56 also does not affect agonist potency at the other adenosine receptor subtypes (A2AR, A2BR, A3R) or the M2 receptor.
A1R PAM 56 (3 μM) significantly enhanced NECA potency for this canonical signaling pathway in primary neuron cultures.
A1R PAM 56 represents a useful pharmacological tool to probe the therapeutic potential of A1R PAMs in the brain with minimal unwanted cardiac effects.
Physicochemical Properties
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M.Wt
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268.38
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Formula
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C16H16N2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(naphthalen-1-yl)-5-propylthiazol-2-amine
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References
1. Nguyen ATN, et al. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2421687122.
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