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AA520

Chemical Structure : AA520

CAS No.: 1904607-15-3

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AA520 (AA-520)

Catalog No.: PC-23590Not For Human Use, Lab Use Only.

AA520 is a potent, dual inhibitor of cyclooxygenase-2 (COX-2) and PPARα with IC50 of 0.1 uM (inhibition of LPS-induced PGE2).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AA520 is a potent, dual inhibitor of cyclooxygenase-2 (COX-2) and PPARα with IC50 of 0.1 uM (inhibition of LPS-induced PGE2).
AA520 dispays exquisite selectivity on PPARα concerning PPARγ, and 697-fold selective over COX-1.
AA520 does not affect LPS-induced monocyte COX-2 expression, and other eicosanoids generated by enzymatic and nonenzymatic pathways.
AA520 inhibited COX-2-dependent PGE2 generation in the colon cancer cell line HCA7. AA520 (1 μM) significantly reduced MTT in HCA7 cells.

Physicochemical Properties

M.Wt 500.99
Formula C25H25ClN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-N-(4-((2-methyl-1-oxo-1-(phenylsulfonamido)propan-2-yl)oxy)phenethyl)benzamide

References

1. Ammazzalorso A, et al. Front Pharmacol. 2024 Nov 26;15:1488722.

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