Catalog No.: PC-24678Not For Human Use, Lab Use Only.
Ligritinib (AB801) is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays.
Ligritinib (AB801) is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays.
AB801 showed extremely high levels of selectivity against MERTK and TYRO3, and only one kinase (DRAK1) showing a <100-fold selectivity ratio against AXL against the human kinome.
30 mg/kg AB801 in combination with sunitinib exhibited a statistically significant reduction in tumor volume in human 786-O clear-cell renal cell carcinoma (ccRCC) xenograft model
