Chemical Structure : AB801
CAS No.:
3024588-48-2
AB801
(AB-801)
Catalog No.: PC-24678Not For Human Use, Lab Use Only.
AB801 is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AB801 is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays.
AB801 showed extremely high levels of selectivity against MERTK and TYRO3, and only one kinase (DRAK1) showing a <100-fold selectivity ratio against AXL against the human kinome.
30 mg/kg AB801 in combination with sunitinib exhibited a statistically significant reduction in tumor volume in human 786-O clear-cell renal cell carcinoma (ccRCC) xenograft model
Physicochemical Properties
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M.Wt
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528.66
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Formula
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C33H32N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-[(7S)-3-[3-[5-(3-Methylpyridin-2-yl)pyridin-2-yl]-1H-pyrazolo[3,4-b]pyridin-5-yl]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]-3-oxa-6-azabicyclo[3.1.1]heptane
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References
1. Miles DH, et al. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00239.
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