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AB801

Chemical Structure : AB801

CAS No.: 3024588-48-2

AB801 (Ligritinib, AB-801)

Catalog No.: PC-24678Not For Human Use, Lab Use Only.

Ligritinib (AB801) is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Ligritinib (AB801) is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays.
    AB801 showed extremely high levels of selectivity against MERTK and TYRO3, and only one kinase (DRAK1) showing a <100-fold selectivity ratio against AXL against the human kinome.
    30 mg/kg AB801 in combination with sunitinib exhibited a statistically significant reduction in tumor volume in human 786-O clear-cell renal cell carcinoma (ccRCC) xenograft model

    Physicochemical Properties

    M.Wt 528.66
    Formula C33H32N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-[(7S)-3-[3-[5-(3-Methylpyridin-2-yl)pyridin-2-yl]-1H-pyrazolo[3,4-b]pyridin-5-yl]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl]-3-oxa-6-azabicyclo[3.1.1]heptane

    References

    1. Miles DH, et al. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00239.

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