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Chemical Structure : ADH-503
CAS No.: 2055362-72-4
Catalog No.: PC-72987Not For Human Use, Lab Use Only.
ADH-503 (GB1275, Leukadherin-1 choline) is a small-molecule allosteric agonist of CD11b that can render tumors more sensitive to checkpoint blockade.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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ADH-503 (GB1275, Leukadherin-1 choline) is a small-molecule allosteric agonist of CD11b that can render tumors more sensitive to checkpoint blockade.
ADH-503 rapidly decreased the genes involved in IL-1 signaling, increased the expression of cytokines involved in T cell and DC trafficking.
ADH-503 reduced the regulatory T cell (Treg) recruitment of cytokines CCL17 and CCL22 in PDAC-activated macrophages, down-regulated TGF-β1, IL-1α, and IL-1β and reduced alternative activation markers arginase-1 (Arg1), YM1, and Retnlα while upregulating type I interferons (IFNα1 and IFNβ) and T cell recruitment factors (CXCL9, CXCL10, and CXCL11).
ADH-503 reduced the numbers of total tumor-infiltrating CD11b+cells and subsets of CD11b+ monocytes, granulocytes, eosinophils, and macrophages on myeloid cells, improves T cell responses in vivo, induces the accumulation of CD103+ cDCs in the tumor.
ADH-503 impairs tumor growth and improves survival in orthotopic models and KPC GEMMs, also improves the efficacy of chemotherapy.
| M.Wt | 524.65 | |
| Formula | C27H28N2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-hydroxy-N,N,N-trimethylethan-1-aminium (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoate |
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1. Panni RZ, et al. Sci Transl Med. 2019 Jul 3;11(499). pii: eaau9240. doi: 10.1126/scitranslmed.aau9240.
2. Geraghty T, et al. Front Oncol. 2020 May 21;10:748.
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