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Chemical Structure : ADT-094
Catalog No.: PC-61345Not For Human Use, Lab Use Only.
ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively.
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ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively.
ADT-094 displays no inhibitory activity for COX-1 and COX-2.
ADT-094 activates cGMP/PKG signaling and suppresses β-catenin/TCF-transcriptional activity, resulting in cell cycle arrest and apoptosis induction.
ADT-094 inhibits the growth of human HCT116 and HT29 colon tumor cell lines (IC50=1 uM).
| M.Wt | 477.557 | |
| Formula | C28H31NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li N, et al. Oncotarget. 2015 Sep 29;6(29):27403-15.
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