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Chemical Structure : AG-1296
Catalog No.: PC-61281Not For Human Use, Lab Use Only.
A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells.
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A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells; potently inhibits signaling of human PDGF alpha- and beta-receptors, c-Kit but has no effect on autophosphorylation of KDR or on DNA synthesis induced by VEGF in porcine aortic endothelial cells.
| M.Wt | 266.3 | |
| Formula | C16H14N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kovalenko M, et al. Biochemistry. 1997 May 27;36(21):6260-9.
2. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14.
3. Lipson KE, et al. J Pharmacol Exp Ther. 1998 May;285(2):844-52.
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