AG-1296 |CAS:146535-11-7 Probechem Biochemicals

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Chemical Structure : AG-1296

AG-1296 (Tyrphostin AG 1296)

Catalog No.: PC-61281Not For Human Use, Lab Use Only.

A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and selective inhibitor of PDGFR with IC50 of about 0.4 uM both in vitro and in cells; potently inhibits signaling of human PDGF alpha- and beta-receptors, c-Kit but has no effect on autophosphorylation of KDR or on DNA synthesis induced by VEGF in porcine aortic endothelial cells.

Physicochemical Properties

M.Wt	266.3
Formula	C16H14N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethoxy-2-phenylquinoxaline

References

1. Kovalenko M, et al. Biochemistry. 1997 May 27;36(21):6260-9.

2. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14.

3. Lipson KE, et al. J Pharmacol Exp Ther. 1998 May;285(2):844-52.

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AG-1296 (Tyrphostin AG 1296)

Biological Activity

Physicochemical Properties

References

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