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Chemical Structure : AMG-579
CAS No.: 1227067-61-9
Catalog No.: PC-60496Not For Human Use, Lab Use Only.
AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
AMG-579 displays high selectivity with IC50 > 30 uM against all other PDE isoforms.
AMG-579 demonstrates excellent target occupancy efficacy in PCP-LMA behavioral model.
| M.Wt | 441.491 | |
| Formula | C25H23N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone |
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1. Hu E, et al. J Med Chem. 2014 Aug 14;57(15):6632-41.
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