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AMG151

Chemical Structure : AMG151

CAS No.: 1138669-65-4

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AMG151 (ARRY-403, ARRY403, AMG-151)

Catalog No.: PC-49834Not For Human Use, Lab Use Only.

AMG 151 (ARRY-403) is an orally available allosteric glucokinase (GK) activator, binds to glucose-bound glucokinase distinctly from glucose- or adenosine triphosphate-binding sites to activate glucokinase selectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMG 151 (ARRY-403) is an orally available allosteric glucokinase (GK) activator, binds to glucose-bound glucokinase distinctly from glucose- or adenosine triphosphate-binding sites to activate glucokinase selectively.

    Physicochemical Properties

    M.Wt 454.52
    Formula C20H18N6O3S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-(5-((3-((2-methylpyridin-3-yl)oxy)-5-(pyridin-2-ylthio)pyridin-2-yl)amino)-1,2,4-thiadiazol-3-yl)ethane-1,2-diol

    References

    1. John Chung, et al. J Pharm Sci. 2015 Apr;104(4):1522-32.

    2. Katz L, et al. Diabetes Obes Metab. 2016 Feb;18(2):191-5.

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