Catalog No.: PC-49476Not For Human Use, Lab Use Only.
ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity.
ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity.
ANA-0 showed cross-subtype protection against influenza A virus infections in vitro and in vivo.
ANA-0 (20 uM) exhibited antiviral effects against infections of H3N2, H5N1, H7N7, H7N9 and H9N2 viruses in cell cultures.
ANA-0 showed IC50 of 2.5 uM against H5N1 and H7N7 viruses.
ANA-0 (2 mg/kg/day, intranasal treatment) inhibited virus growth in mice challenged with LD80 of mouse-adapted H1N1 virus, inhibited the viral transcription.
ANA-0 demonstrated synergistic antiviral effect when combined with zanamivir.
