Catalog No.: PC-72440Not For Human Use, Lab Use Only.
AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.
AQX-435 (AQX435) is a novel small molecule SHIP1 activator, inhibits anti-IgM-induced PI3K-mediated signaling, including induction of AKT phosphorylation and MYC expression, without effects on upstream SYK phosphorylation.
AQX-435 co-operated with the BTK inhibitor ibrutinib to enhance inhibition of anti-IgM-induced AKT phosphorylation.
AQX-435 induced caspase-dependent apoptosis of CLL cells preferentially as compared to normal B cells.
AQX-435 induced TMD8 cell apoptosis in vitro with an IC50 of 2 uM, and overcame in vitro survival promoting effects of microenvironmental stimuli.
AQX-435 reduced AKT phosphorylation and growth of DLBCL in vivo, and co-operated with ibrutinib for tumor growth inhibition.
