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Chemical Structure : AS-252424
CAS No.: 900515-16-4
Catalog No.: PC-22458Not For Human Use, Lab Use Only.
AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.
AS-252424 displays no significant activity over PI3Kβ/δ (IC50>20 uM), as well as excellent selectivity profile against a large set of unrelated protein kinases.
AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration-dependent manner in Raw-264 macrophages (IC50=0.228 uM), with no effect on SCF-induced phosphorylation of PKB/Akt in bone marrow derived mast cells.
AS-252424 inhibits preferentially chemokine-induced (PI3Kγ-mediated) but not cytokine-induced (class IA PI3K-mediated) PKB/Akt phosphorylation in the human monocytic cell line THP-1.
AS-252424 decreases leukocyte infiltration in a murine peritonitis model.
AS-252424 also is a potent ferroptosis inhibitor, directly binds to the glutamine 464 of ACSL4 to inhibit its enzymatic activity.
| M.Wt | 305.28 | |
| Formula | C14H8FNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-5-((5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione |
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1. Pomel V, et al. J Med Chem. 2006 Jun 29;49(13):3857-71.
2. Huang Q, et al. Sci Adv. 2024 Mar 29;10(13):eadk1200.
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