Catalog No.: PC-22458Not For Human Use, Lab Use Only.
AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.
AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.
AS-252424 displays no significant activity over PI3Kβ/δ (IC50>20 uM), as well as excellent selectivity profile against a large set of unrelated protein kinases.
AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration-dependent manner in Raw-264 macrophages (IC50=0.228 uM), with no effect on SCF-induced phosphorylation of PKB/Akt in bone marrow derived mast cells.
AS-252424 inhibits preferentially chemokine-induced (PI3Kγ-mediated) but not cytokine-induced (class IA PI3K-mediated) PKB/Akt phosphorylation in the human monocytic cell line THP-1.
AS-252424 decreases leukocyte infiltration in a murine peritonitis model.
AS-252424 also is a potent ferroptosis inhibitor, directly binds to the glutamine 464 of ACSL4 to inhibit its enzymatic activity.
