Catalog No.: PC-60997Not For Human Use, Lab Use Only.
AS2444697 is a potent, selective, orally bioavailable IRAK4 inhibitor (IC50=21 nM), potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.
AS2444697 is a potent, selective, orally bioavailable IRAK4 inhibitor (IC50=21 nM), potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1.
AS2444697 inhibited IL-1β- or TLR ligand lipopolysaccharide (LPS)-induced IL-6 production in human lung alveolar epithelial cells, fibroblast-like synoviocytes, and peripheral blood mononuclear cells.
AS2444697 significantly reduces urinary protein excretion and preventd the development of glomerulosclerosis and interstitial fibrosis without affecting the blood pressure in mice model of chronic kidney disease.
