Catalog No.: PC-47116Not For Human Use, Lab Use Only.
AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively.
AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively.
AS3334034 concentration-dependently inhibited MDP-induced NF-κB activation in HCT116 cells with IC50 of 4.4 nM.
AS3334034 displays >480-fold selectivity against a great panel of kinases, only partially inhibits several kinase activities at 1 uM, such as discoidin domain receptor and ephrin receptor.
AS3334034 (3-30 mg/kg, p.o.) dose-dependently inhibited MDP-induced increase in plasma MCP-1 level in rats.
AS3334034 (10 mg/kg, once daily, p.o.) significantly reduced urinary protein excretion and prevented the development of glomerulosclerosis and tubulointerstitial fibrosis in uninephrectomized adriamycin-induced CKD rats.
