Chemical Structure : AT-076
CAS No.:
1657028-64-2
AT-076
(AT076)
Catalog No.: PC-20510Not For Human Use, Lab Use Only.
AT-076 (AT076) is the first potent small-molecule opioid pan antagonist with receptor binding Ki values of 1.75, 1.14, 1.67 and 19.6 nM for NOP, KOP, MOP, and DOP, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AT-076 (AT076) is the first potent small-molecule opioid pan antagonist with receptor binding Ki values of 1.75, 1.14, 1.67 and 19.6 nM for NOP, KOP, MOP, and DOP, respectively.
AT-076 demonstrates Ke values of 0.58 and 24.95 nM for inhibition of agonist-stimulated [35S]GTPγS binding curves.
AT-076 shows that it has a noncompetitive antagonist profile at the NOP and KOP receptors (insurmountable antagonism), but is a potent competitive antagonist at the MOP and DOP receptors, with Ke values 3–6-fold more potent than those of JDTic (Cat. PC-42614).
Physicochemical Properties
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M.Wt
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437.58
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Formula
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C26H35N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C([C@@H]1NCC2=C(C=CC(O)=C2)C1)N[C@@H](C(C)C)CN3CCC(C4=CC=CC(O)=C4)CC3
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References
1. Zaveri NT, et al. ACS Chem Neurosci. 2015 Apr 15;6(4):646-57.
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