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Chemical Structure : AT-076
Catalog No.: PC-20510Not For Human Use, Lab Use Only.
AT-076 (AT076) is the first potent small-molecule opioid pan antagonist with receptor binding Ki values of 1.75, 1.14, 1.67 and 19.6 nM for NOP, KOP, MOP, and DOP, respectively.
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AT-076 (AT076) is the first potent small-molecule opioid pan antagonist with receptor binding Ki values of 1.75, 1.14, 1.67 and 19.6 nM for NOP, KOP, MOP, and DOP, respectively.
AT-076 demonstrates Ke values of 0.58 and 24.95 nM for inhibition of agonist-stimulated [35S]GTPγS binding curves.
AT-076 shows that it has a noncompetitive antagonist profile at the NOP and KOP receptors (insurmountable antagonism), but is a potent competitive antagonist at the MOP and DOP receptors, with Ke values 3–6-fold more potent than those of JDTic (Cat. PC-42614).
| M.Wt | 437.58 | |
| Formula | C26H35N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zaveri NT, et al. ACS Chem Neurosci. 2015 Apr 15;6(4):646-57.
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