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Chemical Structure : AT1001
Catalog No.: PC-49428Not For Human Use, Lab Use Only.
AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR).
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AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR).
AT1001 potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR.
AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding.
AT-1001 inhibits nicotine-induced [3H]dopamine release poorly and at significantly higher concentrations compared with mecamylamine and conotoxin MII in nucleus accumbens (NAcs) synaptosomal preparation.
| M.Wt | 309.251 | |
| Formula | C15H21BrN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Toll L, et al. Neuropsychopharmacology. 2012 May;37(6):1367-76.
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