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AZ13705339

Chemical Structure : AZ13705339

CAS No.: 2016806-57-6

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AZ13705339 (AZ 13705339)

Catalog No.: PC-63150Not For Human Use, Lab Use Only.

AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4。
AZ13705339 inhibits cellular pPAK1 inhibition in MCF10A cell line with IC50 of 59 nM.

Physicochemical Properties

M.Wt 629.755
Formula C33H36FN7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzonitrile, 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]-

References

1. McCoull W, et al. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123.

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