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Chemical Structure : AZ7976
Catalog No.: PC-22033Not For Human Use, Lab Use Only.
AZ7976 (AZ-7976) is a potent, highly selective, allosteric relaxin family peptide receptor 1 (RXFP1) agonist with pEC50 of 9.4 in hRXFP1 cAMP assay in CHO-K1 cells, Emax=114%.
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AZ7976 (AZ-7976) is a potent, highly selective, allosteric relaxin family peptide receptor 1 (RXFP1) agonist with pEC50 of 9.4 in hRXFP1 cAMP assay in CHO-K1 cells, Emax=114%.
AZ7976 binds to an allosteric site on RXFP1, does not compete with but rather enhance binding of 125I-relaxin H2.
AZ7976 is 500-fold less potent RXFP1 agonist in rat compared to human RXFP1.
AZ7976 increases heart rate achieving a Cmax at the rRXFP1cAMP EC50 elicited similar directional effects on these parameters as relaxin H2 in rodents.
| M.Wt | 682.65 | |
| Formula | C30H33F7N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Granberg KL, et al. J Med Chem. 2024 Mar 19. doi: 10.1021/acs.jmedchem.3c02183.
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