Brensocatib (AZD7986) | CatC inhibitor

Chemical Structure : AZD7986

CAS No.: 1802148-05-5

AZD7986 (Brensocatib, INS-1007, AZD-7986, INS1007)

Catalog No.: PC-60297Not For Human Use, Lab Use Only.

AZD7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 (cathepsin C, CatC) inhibitor with enzyme and cell pIC50 of 8.4.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$378	In stock
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Biological Activity

AZD7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 (cathepsin C, CatC) inhibitor with enzyme and cell pIC50 of 8.4.
AZD7986 (INS-1007, Brensocatib) shows excellent selectivity over other cathepsins, including cathepsins S, L, B, K, D, E, Z, H, and G.
AZD7986 (INS-1007, Brensocatib) inhibits activation of all three NSPs (NE, Pr3, and CatG) with pIC50 of 7 in human primary bone marrow-derived CD34+ neutrophil progenitor cells.
AZD7986 (INS-1007, Brensocatib) exhibits suitable human PK properties and is a clinical candidate for COPD.

Physicochemical Properties

M.Wt	420.469
Formula	C23H24N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

References

1. Doyle K, et al. J Med Chem. 2016 Oct 27;59(20):9457-9472.

AZD7986 (Brensocatib, INS-1007, AZD-7986, INS1007)

Biological Activity

Physicochemical Properties

References

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