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AhR antagonist SG-02

Chemical Structure : AhR antagonist SG-02

CAS No.:

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AhR antagonist SG-02 (SG-02, SG02)

Catalog No.: PC-22422Not For Human Use, Lab Use Only.

AhR antagonist SG-02 is a potent utrophin modulator /upregulator and functions as an aryl hydrocarbon (AhR) antagonist with excellent binding affinity (Kd=41.68 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AhR antagonist SG-02 is a potent utrophin modulator /upregulator and functions as an aryl hydrocarbon (AhR) antagonist with excellent binding affinity (Kd=41.68 nM).
AhR antagonist SG-02 upregulates utrophin mRNA up to 2.11-fold and protein level up to 2.7-fold at 800 nM, validated through qRT-PCR and Western blot analysis.
SG-02 also exhibits an increased fusion of C2C12 myoblast cells into mature myotubes.
AhR antagonist SG-02 is a potential oral bioavailable drug candidate that could treat the universal DMD population by utrophin upregulation.

Physicochemical Properties

M.Wt 331.37
Formula C16H14FN3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-fluorobenzyl)-6-(methylsulfonyl)quinazolin-2-amine

References

1. Surojit Ghosh, et al. J Med Chem. 2024 May 21. doi: 10.1021/acs.jmedchem.4c00398.

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