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Chemical Structure : AhR antagonist SG-02
Catalog No.: PC-22422Not For Human Use, Lab Use Only.
AhR antagonist SG-02 is a potent utrophin modulator /upregulator and functions as an aryl hydrocarbon (AhR) antagonist with excellent binding affinity (Kd=41.68 nM).
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AhR antagonist SG-02 is a potent utrophin modulator /upregulator and functions as an aryl hydrocarbon (AhR) antagonist with excellent binding affinity (Kd=41.68 nM).
AhR antagonist SG-02 upregulates utrophin mRNA up to 2.11-fold and protein level up to 2.7-fold at 800 nM, validated through qRT-PCR and Western blot analysis.
SG-02 also exhibits an increased fusion of C2C12 myoblast cells into mature myotubes.
AhR antagonist SG-02 is a potential oral bioavailable drug candidate that could treat the universal DMD population by utrophin upregulation.
| M.Wt | 331.37 | |
| Formula | C16H14FN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Surojit Ghosh, et al. J Med Chem. 2024 May 21. doi: 10.1021/acs.jmedchem.4c00398.
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