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Chemical Structure : Azeliragon
CAS No.: 603148-36-3
Catalog No.: PC-45840Not For Human Use, Lab Use Only.
Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine.
Azeliragon (TTP488, PF-04494700) has been shown to inhibit the binding of sRAGE to Aβ1-42 in a fluorescent polarization assay.
Azeliragon (TTP488, PF-04494700) reduces accumulation in the spleen of Aβ peptides and the expression of IL-6 and macrophage colony stimulating factor, reduces both inflammatory markers (TNF-α, TGF-β and IL-1) and CNS amyloid deposition.
| M.Wt | 532.116 | |
| Formula | C32H38ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Propanamine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl- |
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1. Sabbagh MN, et al. Alzheimer Dis Assoc Disord. 2011 Jul-Sep;25(3):206-12.
2. Chen Y, et al. J Immunol. 2008 Sep 15;181(6):4272-8.
3. Burstein AH, et al. BMC Neurol. 2014 Jan 15;14:12.
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