Catalog No.: PC-45840Not For Human Use, Lab Use Only.
Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine.
Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine.
Azeliragon (TTP488, PF-04494700) has been shown to inhibit the binding of sRAGE to Aβ1-42 in a fluorescent polarization assay.
Azeliragon (TTP488, PF-04494700) reduces accumulation in the spleen of Aβ peptides and the expression of IL-6 and macrophage colony stimulating factor, reduces both inflammatory markers (TNF-α, TGF-β and IL-1) and CNS amyloid deposition.
