BAY-826 | TIE-2 inhibitor | Probechem Biochemicals

Chemical Structure : BAY-826

CAS No.: 1448316-08-2

BAY-826 (BAY826)

Catalog No.: PC-35106Not For Human Use, Lab Use Only.

BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM).

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$328	In stock
50 mg	$548	In stock
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Biological Activity

BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM).
BAY-826 binds with similar high affinity to only 4 of 456 kinases, namely, TIE-1,DDR1, DDR2, and LOK (dissociation constant=0.9, 0.4, 1.3, and 5.9 nM).
BAY-826 is highly selective against other angiogenic kinases, such as VEGFR, FGFR, or PDGFR, and affects VEGF-stimulated proliferation of HUVEC only at lM concentrations.
BAY-826 inhibits TIE-2 phosphorylation in vitro and in vivo as demonstrated by suppression of Angiopoietin-1- or Na3 VO4 -induced TIE-2 phosphorylation in glioma cells or extracts of lungs from BAY-826-treated mice.
BAY-826 improves tumor control in syngeneic mouse glioma models.

Physicochemical Properties

M.Wt	558.531
Formula	C26H19F5N6OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyano-N-(2,4-dimethyl-5-(6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl)phenyl)-5-(pentafluoro-l6-sulfanyl)benzamide

References

1. Schneider H, et al. J Neurochem. 2017 Jan;140(1):170-182.

BAY-826 (BAY826)

Biological Activity

Physicochemical Properties

References

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