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Chemical Structure : BAY 1143269
Catalog No.: PC-62896Not For Human Use, Lab Use Only.
BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.
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BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.
BAY 1143269 shows considerable activity against MNK2 (IC50=904 nM), similar binding potency to only 4 out of 395 kinases, including PIM1 (IC50=518 nM).
BAY 1143269 strongly regulates downstream factors involved in cell cycle regulation, apoptosis, immune response and epithelial-mesenchymal transition in vitro or in vivo.
BAY 1143269 demonstrates strong efficacy in patient-derived NSCLC xenograft models.
| M.Wt | 308.341 | |
| Formula | C17H16N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Santag S, et al. Cancer Lett. 2017 Apr 1;390:21-29.
2. Dreas A, et al. Curr Med Chem. 2017;24(28):3025-3053.
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