BAY 1143269 | MNK1 inhibitor | Probechem Biochemicals

Chemical Structure : BAY 1143269

BAY 1143269 (BAY1143269)

Catalog No.: PC-62896Not For Human Use, Lab Use Only.

BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.

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Biological Activity

BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.
BAY 1143269 shows considerable activity against MNK2 (IC50=904 nM), similar binding potency to only 4 out of 395 kinases, including PIM1 (IC50=518 nM).
BAY 1143269 strongly regulates downstream factors involved in cell cycle regulation, apoptosis, immune response and epithelial-mesenchymal transition in vitro or in vivo.
BAY 1143269 demonstrates strong efficacy in patient-derived NSCLC xenograft models.

Physicochemical Properties

M.Wt	308.341
Formula	C17H16N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-[[3-(2-Benzofuranyl)imidazo[1,2-b]pyridazin-6-yl]oxy]-1-propanamine

References

1. Santag S, et al. Cancer Lett. 2017 Apr 1;390:21-29.

2. Dreas A, et al. Curr Med Chem. 2017;24(28):3025-3053.

BAY 1143269 (BAY1143269)

Biological Activity

Physicochemical Properties

References

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