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Chemical Structure : BB2-50F
Catalog No.: PC-21654Not For Human Use, Lab Use Only.
BB2-50F is a bactericidal inhibitor of M. tuberculosis with MIC value of 8 uM (H37Rv), inhibits succinate dehydrogenase and the F1Fo-ATP synthase.
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BB2-50F is a bactericidal inhibitor of M. tuberculosis with MIC value of 8 uM (H37Rv), inhibits succinate dehydrogenase (SDH) and the F1Fo-ATP synthase.
BB2-50F inhibits the growth of M. tuberculosis H37Rv and the BSL2 approved H37Rv auxotrophic-attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with MIC of 8 uM.
BB2-50F inhibits the growth of a panel of 22 M tuberculosis mc2 6206 (ΔleuD, ΔpanCD) mono-resistant mutants isolated against a variety of TB drugs including isoniazid (INH), rifampicin (RIF), BDQ, and PA-824 with a similar MIC as wild-type (WT).
BB2-50F (10X MIC) kills replicating cultures of M. tuberculosis mc2 6230 more rapidly than the current TB drugs BDQ, INH, and RIF.
BB2-50F potentiates the killing of M. tuberculosis by first- and second-line TB antibiotics.
BB2-50F inhibits mycobacterial succinate oxidation, dysregulates the TCA cycle and secretion of TCA cycle metabolites to prevent their intracellular toxicity.
| M.Wt | 393.45 | |
| Formula | C20H23N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cara Adolph, et al. Cell Chem Biol. 2023 Dec 21:S2451-9456(23)00432-4.
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