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Chemical Structure : BH3I-1
CAS No.: 300817-68-9
Catalog No.: PC-42125Not For Human Use, Lab Use Only.
BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
BH3I-1 (BHI1) specifically blocks the BH3-domain-mediated heterodimerization between Bcl-2 family members in vitro and in vivo and induces apoptosis.
BH3I-1 (BHI1) also potently inhibits p53/hDM2 with Kd of 5.3 uM.
| M.Wt | 400.3105 | |
| Formula | C15H14BrNO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 3.9 mg/mL |
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| Chemical Name/SMILES |
3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo- |
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1. Degterev A, et al. Nat Cell Biol. 2001 Feb;3(2):173-82.
2. Wang L, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
3. Porter JR, et al. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
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