Chemical Structure : BH3I-1
CAS No.:
300817-68-9
BH3I-1
(BHI1, BHI-1, BHI 1;BH 3I1)
Catalog No. : PC-42125Not For Human Use, Lab Use Only.
BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4212501
Biological Activity
BH3I-1 (BHI1) is a small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.p53/hDM2 with Kd of 5.3 uM.
Physicochemical Properties
M.Wt
400.3105
Formula
C15H14BrNO3S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 3.9 mg/mL
Chemical Name/SMILES
3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-
References
1. Degterev A, et al. Nat Cell Biol.
2. Wang L, et al. Bioorg Med Chem Lett.
3. Porter JR, et al. Chem Commun (Camb)
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