BI-6c9

Chemical Structure : BI-6c9

CAS No.: 791835-21-7

Catalog No.: PC-49740Not For Human Use, Lab Use Only.

BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$238	In stock
25 mg	$398	In stock
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Biological Activity

BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.
BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
BI-6C9 prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.
BH3 interacting domain death agonist (Bid), a substrate of caspase-8, is activated in the Fas/Apo-1 (CD95), tumor necrosis factor (TNF)-α, and tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptor-mediated cell death.

Physicochemical Properties

M.Wt	471.59
Formula	C23H25N3O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

References

1. Zhou H, et al. Mol Cancer. 2014 Mar 16;13:59.

2. Landshamer, S., et al. Cell Death Differ. 15(10), 1553-1563 (2008).

3. Culmsee, C. et al. J. Neurosci. 25(44), 10262-10272 (2005).

4. Becattini, B.,et al. Proc. Natl. Acad. Sci. USA 103(3), 12602-12606 (2006).

BI-6c9

Biological Activity

Physicochemical Properties

References

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