Chemical Structure : BI-8128
CAS No.:
2769714-36-3
BI-8128
(BI 8128)
Catalog No.: PC-21465Not For Human Use, Lab Use Only.
BI-8128 is a potent, selective, reversible and orally bioavailable fourth generation EGFR inhibitor, potently inhibits oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C797S.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BI-8128 is a potent, selective, reversible and orally bioavailable fourth generation EGFR inhibitor, potently inhibits oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C797S.
BI-8128 demonstrates potent, low nanomolar anti-proliferative activity in Ba/F3 cells that are dependent on the activity of human EGFR variants del19, del19 T790M C797S, L858R, and L858R T790M C797S.
BI-8128 potently inhibits the two major primary oncogenic EGFR variants del19 and L858R, in the presence and absence of the acquired EGFR resistance mutations T790M and C797S, while sparing wild-type EGFR.
Physicochemical Properties
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M.Wt
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610.72
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Formula
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C32H38N10O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1R,4R)-5-(2-(4-(2-methoxyethyl)piperazin-1-yl)-6-(6-(4-methoxypyridin-3-yl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)-2-oxa-5-azabicyclo[2.2.1]heptane
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