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BI 167107

Chemical Structure : BI 167107

CAS No.: 1202235-68-4

BI 167107 (BI-167107, BI167107)

Catalog No.: PC-35028Not For Human Use, Lab Use Only.

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

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Biological Activity

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).
Due to its high potency and slow dissociation from the target BI-167107 was subsequently used to support crystallization of active state β2AR and β2AR-G-protein complexes.

Physicochemical Properties

M.Wt 370.449
Formula C21H26N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-hydroxy-8-(1-hydroxy-2-((2-methyl-1-(o-tolyl)propan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

References

1. Weiss DR, et al. ACS Chem Biol. 2013 May 17;8(5):1018-26.

2. Ring AM, et al. Nature. 2013 Oct 24;502(7472):575-579.

3. Manglik A, et al. Cell. 2015 May 21;161(5):1101-1111.

4. Kahsai AW, et al. Nat Chem Biol. 2016 Sep;12(9):709-16.

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