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BI 1810284

Chemical Structure : BI 1810284

CAS No.: 2913177-47-4

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BI 1810284 (ACBI2, BI-1810284, BI 01810284)

Catalog No.: PC-20464Not For Human Use, Lab Use Only.

BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.
    BI 1810284 (80 mg/kg, oral) induces lung cancer tumour growth inhibition in A549 tumour bearing mice.

    Physicochemical Properties

    M.Wt 1063.19
    Formula C57H69BrFN7O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Pyrrolidinecarboxamide, N-[(1S,4S)-6-[4-(4-bromo-7-cyclopentyl-5,7-dihydro-5-oxobenzimidazo[1,2-a]quinazolin-9-yl)-1-piperidinyl]-4-methyl-1-[4-(4-methyl-5-thiazolyl)phenyl]hexyl]-1-[(2S)-2-[2-(1-fluorocyclopropyl)-2-oxoethyl]-3,3-dimethyl-1-oxobutyl]-4-hydroxy-, (2S,4R)-

    References

    1. Christiane Kofink, et al. Nat Commun. 2022 Oct 10;13(1):5969.

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