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Chemical Structure : BI 1810284
CAS No.: 2913161-19-8
Catalog No.: PC-20464Not For Human Use, Lab Use Only.
BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.
BI 1810284 (80 mg/kg, oral) induces lung cancer tumour growth inhibition in A549 tumour bearing mice.
| M.Wt | 1063.19 | |
| Formula | C57H69BrFN7O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrrolidinecarboxamide, N-[(1S,4S)-6-[4-(4-bromo-7-cyclopentyl-5,7-dihydro-5-oxobenzimidazo[1,2-a]quinazolin-9-yl)-1-piperidinyl]-4-methyl-1-[4-(4-methyl-5-thiazolyl)phenyl]hexyl]-1-[(2S)-2-[2-(1-fluorocyclopropyl)-2-oxoethyl]-3,3-dimethyl-1-oxobutyl]-4-hydroxy-, (2S,4R)- |
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1. Christiane Kofink, et al. Nat Commun. 2022 Oct 10;13(1):5969.
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