Chemical Structure : BKS-112
CAS No.:
2366253-10-1
BKS-112
(BKS112)
Catalog No.: PC-25804Not For Human Use, Lab Use Only.
BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1.
BKS-112 exhibits selective cytotoxicity toward cancer cells while showing significantly reduced toxicity in MCF-10A normal cells.
BKS-112 exhibits selective cytotoxicity toward cancer cells while showing significantly reduced toxicity in MCF-10A normal cells.
BKS-112 (50 uM) significant increases the expression of acetylated histones in MDA-MB-231 cells.
BKS-112 reduces cell migration, demonstrating anti-metastatic potential, induces G1 phase cell cycle arrest and modulates key regulators, including cyclins and cyclin-dependent kinases (CDKs).
BKS-112 also elevatesreactive oxygen species (ROS) levels, affecting apoptosis-related PI3K/AKT signaling, triggers autophagy by upregulating LC3 and Atg-7 expression.
Physicochemical Properties
|
M.Wt
|
292.33
|
|
Formula
|
C14H13FN2O2S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(E)-N-hydroxy-3-(2-(4-fluorostyryl) thiazol-4-yl) propanamide
|
References
1. Nam G, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3408-3420.
2. Gali S, et al. Antioxidants (Basel). 2025 Oct 28;14(11):1291.
Contact Us
sales@probechem.com
